The number of mergers and acquisitions struck within the pharma and biotechnology sector might have dimmed last year but some pretty sizeable deals happened. Topping the table were Takeda’s $13.1bn takeover of Nycomed and Gilead’s surprise $11bn swoop on Pharmasset – deals not dissimilar in price, but for vastly different assets.
Traditional big pharma is notable by its absence from the top ten deals – Sanofi-Genzyme was announced the year before so is classified as a 2010 deal – although serial acquirer Teva makes two appearances. Meanwhile average deal values recovered substantially last year, encouraging news for those hoping to find a suitor (see tables).
|Average deal values for disclosed deals|
|DealDate||Total Value ($bn)||Total Count||Average deal value ($m)|
|* excludes deals above $20bn|
The table above, calculated using only those deals for which terms were revealed, shows the average M&A deal value climbed 40% last year, to $615m, back towards pre-credit crunch levels. The number of deals actually fell quite substantially, showing that for deals that did get done, sellers were able to extract sizeable price tags. In an attempt to capture underlying deal trends for drug developers it excludes deals over $20bn and any transaction in the medtech or diagnostics space.
The huge takeout of Pharmasset no doubt helped boost average deal value substantially last year; Gilead’s desire to spend $11bn on the back of phase II data set a new benchmark for risky M&A decisions (History not on Gilead's side in high stakes gamble on Pharmasset, November 24, 2011).
An analysis published yesterday found that, excluding Johnson & Johnson’s acquisition of Synthes, traditional big pharma companies spent only $1.2bn on eight M&A deals last year (M&A deal activity dims in 2011 as big pharma backs off, January 31, 2012). The table below breaks down deal making by market cap of the acquirer even further, over the last five years. Again the analysis only includes deals struck in the drug development sector and excludes $20bn plus transactions.
The lack of activity by the biggest companies – such as Pfizer, GlaxoSmithKline and Roche – is clearly apparent, at the lowest levels in recent years. The next group down made a fairly big contribution, and includes deals struck by Takeda, Teva and Bristol-Myers Squibb.
Deal making by companies worth $5bn-$15bn meanwhile shot up, as transactions including Alexion’s $1.1bn bid for Enobia, Forest Lab’s $1.3bn takeover of Clinical Data and Shire’s purchase of Advanced BioHealing were struck.
The absence of big pharma from the buyers' market - and its ability to write huge cheques – could certainly have helped smaller groups get a look in last year. Whether the industry’s very largest companies return to the M&A scene in any number remains to be seen. Deal flow seen this year – such as Celgene’s acquisition of Avila for $350m upfront and Amgen’s $1.1bn bid for Micromet - suggests bigger companies remain in the market.
|Deals struck by market cap of acquirer|
|Deal Date||Value ($bn)||Count||Value ($bn)||Count||Value ($bn)||Count||Value ($bn)||Count||Value ($bn)||Count|
|* excludes deals above $20bn|
The table below shows the biggest transactions of 2011 and 2010. No traditional big pharma name makes the list, although arguably Teva and Amgen could be classified in this group now and possibly even Gilead.
Roche’s $5.7bn bid for Illumina last week is the biggest potential transaction to be announced so far this year, but it is unlikely to be largest. With companies including AstraZeneca, Eli Lilly and even Merck & Co struggling to fill pipelines, a much more substantial deal for 2012 could well be on the cards.
|Top 10 Pharma/Biotech M&A Deals in 2011 and 2010|
|Year||Rank||Acquiring Company||Deal Type||Target||Deal Value ($bn)||Status||Financing Structure|
|2||Gilead Sciences||Company Acquisition||Pharmasset||11.0||Closed||Cash|
|3||Teva Pharmaceutical Industries||Company Acquisition||Cephalon||6.8||Closed||Cash|
|4||Forest Laboratories||Company Acquisition||Clinical Data||1.3||Closed||Cash|
|5||Alexion Pharmaceuticals||Company Acquisition||Enobia Pharma||1.0||Open||Cash|
|7||Alkermes||Business Unit||Elan Drug Technologies||1.0||Closed||Share Exchange + Cash|
|8||Daiichi Sankyo||Company Acquisition||Plexxikon||0.9||Closed||Cash|
|9||Teva Pharmaceutical Industries||Majority Stake||Taiyo Pharmaceutical Industry||0.9||Closed||Cash|
|10||Shire||Company Acquisition||Advanced BioHealing||0.8||Closed||Cash|
|2010||1||Novartis||Majority Stake + Company Acquisition||Alcon||38.0||Closed||Share Exchange + Cash|
|3||Teva Pharmaceutical Industries||Company Acquisition||ratiopharm||5.0||Closed||Cash|
|4||Valeant Pharmaceuticals International||Company Acquisition||Biovail||4.5||Closed||Share Exchange + Cash|
|5||Astellas Pharma||Company Acquisition||OSI Pharmaceuticals||4.0||Closed||Cash|
|6||Abbott Laboratories||Business Unit||Piramal Healthcare Solutions business||3.8||Closed||Cash|
|7||Pfizer||Company Acquisition||King Pharmaceuticals||3.6||Closed||Cash|
|8||Grifols||Company Acquisition||Talecris Biotherapeutics||3.4||Closed||Share Exchange + Cash|
|9||Celgene||Company Acquisition||Abraxis BioScience||2.9||Closed||Share Exchange + Cash|
|10||Johnson & Johnson||Company Acquisition||Crucell||2.2||Closed||Cash|
All data sourced to EvaluatePharma.