Otsuka buys Recor on cusp of US approval trial

In 2015, when Otsuka led Recor Medical’s $15m series B round, renal denervation was a very risky bet. Medtronic’s first-in-class device had tanked in its pivotal US trial and all renal denervation devices, including Recor’s Paradise system, were considered almost defunct. But Recor, alone among the smaller denervation groups, held faith, and when Medtronic’s next-generation device posted good results a year ago the Silicon Valley-based company was well placed to capitalise on the giant’s success. Positive mid-stage trial results with Paradise followed this May, and last week the FDA approved the start of a US approval trial of Paradise, Radiance-II. The sham-controlled study will test Paradise in patients with moderate hypertension; enrolment is to start in October but it is not yet clear how big this trial will be or when it might report. Otsuka’s purchase of Recor, announced today, is therefore a much safer – and likely much more expensive, though the deal’s value was not disclosed – use of its money.

Ongoing trials of Recor's Paradise system
Trial name Status Sponsors Sham control? N NCT ID Results
Radiance-II (US pivotal) Yet to start Otsuka Yes - - Unknown; trial to start in October
Require Recruiting Jimro (Otsuka subsidiary) Yes 140 NCT02918305 Expected December 2018
Radiance-HTN Recruiting Recor Medical Yes 292 NCT02649426 Solo cohort hit in May 2018; Trio cohort data expected August 2018

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