Resurgent Arqule climbs on targeted therapy hope

Snippets

You might be forgiven for thinking that Arqule was down and out, but since the 2013 failure of tivantinib the group has enjoyed an amazing turnaround. This is thanks to repositioning itself around five targeted oncology projects, one of which, the BTK inhibitor ARQ 531, caused its stock to surge 67% yesterday. It is hoped that ARQ 531 could treat patients with the C481S resistance mutation that can develop in response to treatment with a BTK inhibitor like Imbruvica or Calquence. While Arqule reckons the project could treat wild-type patients as well as C481S mutants, the latter represents its fastest route to market, and it was this that helped send the stock up yesterday: a single Calquence-relapsed leukaemia subject treated with ARQ 531 was documented to harbour this mutation, and reported a partial remission, with an 88% tumour burden reduction. Apart from the obvious caveat that this was just a response in one patient, the high ARQ 531 dose involved, 65mg, was associated with serious rash, a dose-limiting toxicity, in another subject. Nevertheless, Arqule today boasts a $593m market cap, and its stock is back where it was before a safety scare spelled the beginning of the end of tivantinib.

Selected Arqule targeted oncology assets
Project Mechanism 2024e sales ($m) Oncology focus Trial ID
Miransertib/ARQ 092 Pan-AKT inhibitor 220 AKT or PI3kmut pts NCT02476955
ARQ 531 W/T & C481Smut BTK inhibitor 140 Post-BTK inhibitor pts NCT03162536
Derazantinib/ARQ 087 FGFR inhibitor 22 FGFR2 fusion cholangiocarcinoma NCT03230318
ARQ 761 NQO1 inhibitor 0 NQO1-high pts NCT02514031
ARQ 751 Next-gen AKT inhibitor 0 AKT, PI3k & PTENmut pts NCT02761694
Source: EvaluatePharma & clinicaltrials.gov.

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