The Medicines Company needs to show decent efficacy and pristine safety with its long-lasting PCSK9 inclisiran to stand a chance of disrupting the market.
Alnylam looks likely to get approval for its second RNAi candidate, givosiran. But toxicity issues have tainted the Envision trial win.
Alnylam appears to have turned its Onpattro launch around, but is adamant that investors should have been more patient all along.
Pharma and biotech takeover activity slumps to a five-year low in 2017.