All attempts to treat Alzheimer’s disease with anti-amyloid drugs have ended in failure, and Novartis and Amgen’s Bace1 inhibitor CNP520 is no different. The partners, along with their academic partner, the Banner Alzheimer’s Institute, have canned the asset after some patients had worsening of cognitive function. This has been seen with other Bace inhibitors; Eli Lilly cited such concerns when it scrapped a couple of similar assets last year. Also known as umibecestat, CNP520 was being tested in two phase III trials in preventative settings. The Generation S1 trial was testing CNP520 along with Novartis’s amyloid vaccine ACD106, and the Generation S2 study tested CNP520 alone; together they were set to enrol more than 3,000 patients. The situation is not great for Novartis but far worse for Amgen – to get the CNP520 collaboration Amgen granted Novartis joint marketing rights to the migraine drug Aimovig. The news raises the pressure on Biogen and Eisai, which have somewhat controversially pushed on with their Bace inhibitor, elenbecestat. This project is also in phase III, with data expected at the Alzheimer’s Association International Conference next week.
|Phase III trials of CNP520 and elenbecestat|
|Novartis/Amgen||CNP520/ umibecestat||Generation S1||1,340||NCT02565511|