Cliffhanger: Portfolio Tactics to Scale the $300bn Patent Cliff

By the end of the decade, prescription drugs generating more than $300bn in revenues will lose patent protection, exposing them to generic and biosimilar competition.

With annual expiries peaking at $104bn in 2028, biopharma faces a concentrated risk that could reshape the industry’s growth outlook.

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About this webinar

This webinar will unpack the scale of the impending patent cliff, spotlight the top 10 drugs facing expiry, and reveal how large pharma’s growth gap is driving new portfolio strategies.

  • What is the potential impact of loss of exclusivity for leading pharma companies?
  • What are the strategies that portfolio teams can adopt to sustain growth through the patent cliff?
  • What lessons can be learned from the blockbusters of the past?
  • How can biopharma companies bridge the growth gap if dealmaking alone won’t cut it?

Speakers

daniel-chancellor

Daniel Chancellor

VP Thought Leadership, Norstella
daniel-di-gaudio

Daniel Di Gaudio

Senior Associate, Evaluate Consulting & Analytics
jessica-merrill-round

Jessica Merrill

Senior Editor,
Scrip

Frequently Asked Questions

The patent cliff refers to the period when major prescription drugs lose exclusivity, exposing them to generic and biosimilar competition. This can result in significant revenue loss and strategic challenges for pharma companies.

Brands like Keytruda, Darzalex, Eliquis, and Opdivo are among the top ten expiries, with Merck, Bristol Myers Squibb, and Pfizer facing the largest portfolio risks.

Strategies include future-proofing portfolios, bolt-on acquisitions, transformational M&A, and aggressive lifecycle management of existing assets.

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