Ionis gives a lesson in financial engineering


The mystery behind Ionis’s decision in 2015 to form Akcea, a wholly owned subsidiary, deepened two years later when a minority stake in the unit was floated on Nasdaq. Yesterday the plot thickened further after Ionis did a partial U-turn and seized greater control of Akcea.

Ostensibly the development puts another Ionis asset in Akcea’s hands, but since Ionis continues to control everything the “deal” is illusory. Rather, the transaction is about cash allocation and financial engineering, and the result – Akcea stock surged 38% yesterday – will have deal bankers rubbing their hands with glee.

Bankers pitching similar deals now have an excellent case study to back up the idea that setting up arm’s-length units is capable of releasing hidden value: since the minority Akcea stake was floated last July its stock has nearly tripled in value, while that of Ionis is broadly unchanged.

IPO catalyst

It also helps that Novartis is an important ally for two Ionis projects that had been assigned to Akcea – AKCEA-APO(a)-LRx and AKCEA-APOCIII-LRx.

Indeed, the striking of an option deal for these in early 2017 served as the catalyst for the subsequent IPO, in which the Swiss company bought $50m of Akcea stock. The other two assets assigned by Ionis to its Akcea subsidiary were volanesorsen (now filed for familial lipoprotein lipase deficiency) and AKCEA-ANGPTL3-LRx.

The main point of yesterday’s transaction was for Ionis to transfer more cash to Akcea – $200m to be precise – in return for an increased equity stake. As an aside Ionis also assigned to its subsidiary another asset, inotersen, which is awaiting approval for TTR amyloidosis and is in phase III studies for familial amyloid polyneuropathy.

Inotersen had been licensed to Glaxosmithkline, but the UK group handed it back to Ionis last year (Ionis absorbs Glaxo rare disease cull, August 11, 2017). While at the time names like Pfizer had been bandied around as potential new partners, yesterday’s move means that Ionis has had to go it alone – though it has of course been able to dress up its shifting of the asset to Akcea as a worldwide commercialisation deal.

Follow the money: how Ionis and Akcea are related
Date Event Ionis equity interest in Akcea
Q1 2017 Novartis invests $100m in Ionis equity 100%
Jun 2017 Akcea's 4% credit line from Ionis stands at $106m 100%
Jun 2017 Novartis licenses 4 Ionis assets; $60m cash accrues to Akcea, $15m to Ionis 100%
Jul 2017 $106m credit line is extinguished in IPO of minority Akcea interest 68%
Jul 2017 New shareholders invest $132m in Akcea equity at IPO 68%
Jul 2017 Novartis invests $50m in Akcea equity at IPO 68%
Mar 2018 Ionis assigns inotersen to Akcea for $150m of Akcea equity 71%
Mar 2018 Ionis invests $200m in Akcea equity 75%
Possible in future Ionis stands to get <$90m of Akcea equity on inotersen approval(s) >75%
Possible in future Novartis option exercise: $75m cash accrues to Akcea, $75m to Ionis >75%
Source: SEC filings.

There is one final irony about yesterday’s transaction: approval of inotersen, expected this year, will trigger up to $90m of what the companies term “milestone payments” from Akcea to Ionis, and these “may be payable in Akcea common stock”. Of course this amounts to nothing more than Ionis being assigned a yet greater share of Akcea equity.

So far the markets have been extremely kind to Akcea, enabling Ionis to boast that it now owns majority control of a business that in the space of less than a year has tripled in value. But until Akcea is an unencumbered entity it is unlikely to attract more than short-term investor interest.

And until Ionis moves in the opposite direction – reducing the control it has over Akcea and seeking to spin it off entirely – the minutiae of which group markets which of its drugs will continue to be irrelevant.

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