Groups slam Philip Morris, but the Vectura deal has precedent

Six respiratory health societies have slammed the recent takeover by Philip Morris of the UK drug delivery biotech Vectura, but the move, seeking to prevent tobacco companies from benefiting from such acquisitions, comes somewhat late to the game. Friday’s joint statement bans employees of tobacco-owned companies from featuring data in journals or meetings run by the European Respiratory Society, American Thoracic Society, International Union Against Tuberculosis and Lung Diseases, Asian Pacific Society of Respirology, Asociación Latino Americana De Tórax, and Global Initiative for Asthma. No products of tobacco-owned companies will be promoted at the groups’ future scientific meetings or co-sponsored conferences. This mirrors a similar stance taken by the British Thoracic Society, which last month ran an editorial entitled “Vectura and Philip Morris: the leopard has not changed its spots”. This could discourage moves such as BAT setting up a biotech business, Kbio, to use a plants to develop treatments for rare and infectious diseases. However, tobacco companies like Japan Tobacco have a long history of investing in drug development. Philip Morris itself has held a stake in Medicago, a Canadian player seeking to enter Covid vaccine business, since 2008, and last year bought Fertin Pharma and Oti-Topic too.

A history of drug development: selected projects with tobacco company involvement
Project Indication Status Current owner Originator
Vitekta (elvitegravir) HIV Marketed Gilead Sciences Japan Tobacco
Mekinist Melanoma Marketed Novartis Japan Tobacco
Enaroy (enarodustat) Chronic kidney disease Marketed Torii Pharmaceutical Japan Tobacco
Flutiform Asthma Marketed Mundipharma (royalty now payable to Philip Morris) Skyepharma
Enerzair Breezhaler Asthma Marketed Novartis (royalty now payable to Philip Morris) Vectura
AirFluSal Forspiro COPD/asthma Marketed Novartis (royalty now payable to Philip Morris) Vectura
Ultibron Neohaler COPD Marketed Novartis (royalty now payable to Philip Morris) Vectura
Hualan Influenza vaccine Marketed Hualan Biological Engineering Medicago (20% owned by Philip Morris)
MT-2271 Influenza vaccine Filed Mitsubishi Chemical Medicago (20% owned by Philip Morris)
MT-2766 Covid vaccine Filed Mitsubishi Chemical Medicago (20% owned by Philip Morris)
Dalcetrapib Hyperlipidaemia Phase 3 Dalcor Pharmaceuticals Japan Tobacco
MK-5442 Osteoporosis  Discontinued Merck & Co Japan Tobacco
MEDI-570 Cancer Discontinued Astrazeneca Japan Tobacco
Bradanicline Schizophrenia Discontinued Catalyst Biosciences Targacept (RJ Reynolds spin-out)
TC-6987 Asthma Discontinued Catalyst Biosciences Targacept (RJ Reynolds spin-out)
Source: Evaluate Pharma.

This story has been amended to clarify detail in the table.

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