Dropping the Bace

Vantage Data Points

The last of the clinical-stage beta-secretase (Bace) inhibitors in Alzheimer's disease is dead. Biogen and its partner Eisai's decision to discontinue ongoing studies of elenbecestat signals the end for this once-popular mechanism of action. Below is a summary of all the other Bace inhibitor projects that have fallen by the wayside in the past few years. 

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