Regeneron’s IL-33 “win” looks like bad news for Anaptysbio

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Regeneron and Sanofi have claimed a win in the first proof-of-concept trial with their anti-IL-33 MAb REGN3500 (SAR440340), a potential successor to Dupixent. However, REGN3500 merely beat placebo in the phase II asthma trial. The study also included the anti-IL-4/IL-13 MAb Dupixent, which numerically beat the newcomer, while a combination of the two agents did not outperform Dupixent alone. The data raise questions about whether further development of REGN3500 is worthwhile but, perhaps more importantly, look like bad news for Anaptysbio, whose lead project, etokimab, also hits IL-33. Anaptysbio, which is awaiting readout of the Atlas trial in atopic dermatitis, saw its stock open down 15% today. The latest data suggest that IL-33-targeting drugs could at best be similar to Dupixent. If this is borne out in Atlas etokimab would find it difficult to compete in what are crowded sectors. As well as atopic dermatitis the company is taking aim at asthma, where Dupixent is already approved, and nasal polyps, where it soon could be. Glaxosmithkline might also want to re-evaluate its anti-IL-33 contender, GSK3772847, which it previously highlighted as its most promising respiratory project.

As good, but not better? The IL-33 pipeline
Project Company/ies Indication Trial Primary completion
Phase II
REGN3500 (SAR440340)  Sanofi/Regeneron Asthma NCT03387852 Reported
    COPD NCT03546907 Dec 2019
    Atopic dermatitis NCT03736967, NCT03738423 Both Mar 2020 
Etokimab Anaptysbio Atopic dermatitis Atlas, NCT03533751 Jun 2019
    Nasal polyps NCT03614923 Dec 2019
    Asthma PhIIb planned this year -
GSK3772847 Glaxosmithkline/J&J Asthma NCT03207243, NCT03393806 Feb 2019, Oct 2019
Phase I
MEDI3506 Astrazeneca COPD NCT03096795 Sep 2019
Source: EvaluatePharma, clinicaltrials.gov.

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